During the time of war, the five major poison sects rose up across the martial arts world, corresponding to the five poisons in life. The leader of the Sacred Scale Sect, Nangong Yi, seeks to satisfy his selfish desires by stealing the martial arts manuals from various sects. One fateful night, a fierce wind arose. The leader of the Heavenly Dragon Sect disappeared, the Golden Crow Sect was exterminated, and Tianchan Valley vanished overnight. During the chase, the youngest son of the Tianchan Valley's leader, Dugu Yu, was saved by the elder Dugu Zhong using toad kung fu and was raised by a rural old woman, as his grandmother. Eighteen years later, Dugu Yu meets Nangong Ling, and they develop feelings for each other, not realizing that she is the daughter of his arch-enemy, Nangong Yi, who has been searching for Dugu Yu for eighteen years. When Dugu Yu is captured, Ling risks her life to rescue him. In an accident, Dugu Yu falls off a cliff and masters the toad kung fu. Dugu Yu goes to take revenge on Nangong Yi, but Nangong Ling sacrifices herself to end the conflict. Nangong Yi personally kills his beloved daughter, losing his sanity and becoming a madman. In the end, Dugu Yu also lets go of his grudges.
