On this night, in a grand mansion in Weizhou, a woman with disheveled hair crawled out of her bed, holding a bloody short knife in her hand. The owner of the house, Diao Sihu, was found dead on the spot... On another night, Xu Jian, the richest man in Guangzhou, attempted to push a woman onto the bed, only to find that death was beckoning him... On this night, Zhou Qi, a wealthy businessman from Chizhou, married a concubine, but the next day he was found brutally murdered... Bao Zheng (played by Jin Chaoqun) was lost in thought. He was on a tour in Chizhou when he encountered the Zhou Qi case, and during the investigation, he surprisingly uncovered a web of mystery—three deceased individuals seemed not to know each other, yet all died on their wedding nights, and after the bloody incidents, the brides mysteriously disappeared. Strangely, all the victims were wealthy businessmen with a taste for women, all killed in their bedrooms, and the cause of death was not from knife wounds, but from the venom of a black widow spider. Bao Zheng went to Guangzhou to visit relatives and began investigating the spider poison case, discovering that the three deceased were sworn brothers from Yangzhou, and that the richest man in the area, Ba Renjie (played by Lu Yilong) and Ba Renfeng (played by Yang Zhong'en), were all in cahoots. The Ba brothers even colluded with Governor Shi Cuilu (played by Wu Ma) to obstruct the investigation. At this time, a talented and beautiful courtesan named Haitang (played by Zhen Xiuzhen) arrived at Guangzhou's Wanhualou, attracting the lustful attention of Ba Renjie. One day, Haitang and her maid Qiuer were harassed in the street, and thankfully, Zhan Zhao (played by Jiao Enjun) came to their rescue. The guard, Zhan, was enchanted by the cold and charming Haitang, only to later realize she was a renowned courtesan. Struggling with unrequited love, the hero Zhan proposed to Haitang, but she had long put aside her romantic aspirations, willing to nurture spider venom with her own blood to exact revenge for a twelve-year-old unsolved case...